An update on the pathophysiology and pharmacology of Alzheimer's disease

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease. Plaques and tangles are described as the characteristic features of AD, which are neurotoxic entites, deposited in the diseased patients. There are very few drugs available for the treatment of AD. Those available options are primarily the approaches to overcome cholinergic hypofunction, through the inhibition of acetylcholinestrase enzyme. Other disease modifiying candidates are strongly needed to overcome the progressive dementia in AD. These new drugs will serve as a great hope for the AD patients and families of the AD patients.