Lumpy skin disease in Pakistan: unraveling the outbreak and charting future horizons

Authors

  • Farrakh Ali Abbas University of Sargodha, Sargodha, Pakistan
  • Shazia Batool University of Sargodha, Sargodha, Pakistan
  • Imran Riaz Malik University of Sargodha, Sargodha, Pakistan
  • Arshad Abbas University of Sargodha, Sargodha, Pakistan
  • Zeenat Nawaz Govt. Graduate College, Garh Maharaja, Ahmadpur Sial, Jhang, Pakistan
  • Muhammad Shafique Govt College University, Faisalabad, Pakistan
  • Lubowa Muniiru International Islamic University in Uganda, Uganda

DOI:

https://doi.org/10.53992/njns.v10i1.248

Keywords:

Lumpy skin disease, Capripoxvirus, Livestock epidemics, Agricultural economics in Pakistan, Integrated disease control strategies

Abstract

Lumpy skin disease (LSD) emergence in Pakistan threatens agricultural economics centered on endemic bovine species. Originally restricted to Africa, LSD epidemics recently disseminated to Middle East and South Asia via infected cattle imports and biting vectors. The 2021 outbreak in Pakistan, which involved over 220,000 cases, was examined with respect to transmission among smallholder herds, diagnostic challenges, control measures, and research priorities concerning this Capripoxvirus. Clinical manifestations include hide lesions and debilitating lactation reductions. Initial cases likely originated from cross-border animal movement. Dominant transmission involves arthropod vectors while herd immunity remained nonexistent enabling spread to naive cattle populations across provinces. Ring vaccinations around detected cases therefore focused on sheeppox or goatpox inoculums - albeit suboptimal protection - complemented by quarantines and animal tracing. However, localized, inability to curb outbreak emphasizes poor vaccine access and movement control. As Pakistan's livestock sector constitutes 60% agricultural GDP across mostly smallholder production, LSD inflicts serious socioeconomic repercussions. Quantifying burden and livestock-specific transmission dynamics is thus imperative to prevent future LSD epidemics through integrated approaches blending vaccination, surveillance, farmer training, and advocacy of evidence-based control policies suited for Pakistan's unique circumstances. The research explores the 2021 LSD outbreak in Pakistan to examine its economic impact combined with disease transmission patterns alongside obstacles for disease management. The study combines epidemiological evidence with real-world control approaches to deliver critical guidelines for policymakers and veterinary practitioners who aim to enhance LSD preventative and response systems in Pakistan.

References

Al-Salihi K. Lumpy skin disease: Review of literature. Mirror of research in veterinary sciences and animals. 2014;3(3):6-23.

Tuppurainen E, Alexandrov T, Beltrán-Alcrudo D. Lumpy skin disease-a manual for veterinarians. FAO Animal Production and Health Manual. 2017(20).

Davies FG. Lumpy skin disease, an African capripox virus disease of cattle. British Veterinary Journal. 1991;147(6):489-503.

Abutarbush SM, Ababneh MM, Al Zoubi IG, Al Sheyab OM, Al Zoubi MG, Alekish MO, et al. Lumpy Skin Disease in Jordan: Disease Emergence, Clinical Signs, Complications and Preliminary-associated Economic Losses. Transboundary and Emerging Diseases. 2015;62(5):549-554.

Tuppurainen ESM, Lubinga JC, Stoltsz WH, Troskie M, Carpenter ST, Coetzer JAW, et al. Evidence of vertical transmission of lumpy skin disease virus in Rhipicephalus decoloratus ticks. Ticks and Tick-borne Diseases. 2013;4(4):329-333.

Rgbe H. Lumpy skin disease (LSD): outbreak investigation, isolation and molecular detection of lumpy skin disease in selected areas of eastern

Shewa, Ethiopia. AAU. 2014:72.

Wainwright S, El Idrissi A, Mattioli R, Njeumi F, Raizman E, Tibbo M. Emergence of lumpy skin disease in the Eastern Mediterranean Basin countries. 2013.

Roche X, Rozstalnyy A, TagoPacheco D, Pittiglio C, Kamata A, Beltran Alcrudo D, Bisht K, Karki S, Kayamori J, Larfaoui F, Raizman E. Introduction and spread of lumpy skin disease in South, East and Southeast Asia: Qualitative risk assessment and management. Food & Agriculture Org; 2021 Mar 30.

Khan YR, Ali A, Hussain K, Ijaz M, Rabbani AH, Khan RL, Abbas SN, Aziz MU, Ghaffar A, Sajid HA. A review: Surveillance of lumpy skin disease (LSD) a growing problem in Asia. Microbial pathogenesis. 2021 Sep 1;158:105050.

Khatri G, Rai A, Aashish, Shahzaib, Hyder S, Priya, Hasan MM. Epidemic of lumpy skin disease in Pakistan. Veterinary Medicine and Science. 2023 Mar;9(2):982-984.

King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ. Virus taxonomy. Ninth report of the International Committee on Taxonomy of Viruses. 2012;9.

Tulman ER, Rock DL, Zsak L, Afonso CL, Lu Z, Kutish GF. Genome of lumpy skin disease virus. Journal of Virology. 2001;75(15):7122-7130.

Tulman ER, Afonso CL, Lu Z, Zsak L, Kutish GF, Rock DL. Genome of Lumpy Skin Dis Virus. Journal of Virology. 2001;75(15):7122-7130.

Liang Z, Yao K, Wang S, Yin J, Ma X, Yin X, Wang X, Sun Y. Understanding the research advances on lumpy skin disease: A comprehensive literature review of experimental evidence. Frontiers in Microbiology. 2022 Nov 28;13:1065894.

OIE. Lumpy Skin Disease [Internet]. World Organization for Animal Health: World Organization for Animal Health. [cited 2023]. Available from: https://www.woah.org/en/disease/lumpy-skin-disease/.

Mellor PS, Kitching RP, Wilkinson PJ. Mechanical transmission of capripox virus and African swine fever virus by Stomoxys calcitrans. Research in veterinary science.1987;43(1):109-112.

Weiss K, Gard S. Cytomegaloviruses. Rinderpest virus. Lumpy skin disease virus: Springer; 2013.

Chihota CM, Rennie LF, Kitching RP, Mellor PS. Attempted mechanical transmission of lumpy skin disease virus by biting insects. Medical and Veterinary Entomology. 2003;17(3):294-300.

Tuppurainen ESM, Stoltsz WH, Troskie M, Wallace DB, Oura CAL, Mellor PS, et al. A Potential Role for Ixodid (Hard) Tick Vectors in the Transmission of Lumpy Skin Disease Virus in Cattle. Transboundary and Emerging Diseases. 2011;58(2):93-104.

Gari G, Abie G, Gizaw D, Wubete A, Kidane M, Asgedom H, et al. Evaluation of the safety, immunogenicity and efficacy of three capripoxvirus vaccine strains against lumpy skin disease virus. Vaccine. 2015;33(28):3256-3261.

Irons PC, Tuppurainen ESM, Venter EH. Excretion of lumpy skin disease virus in bull semen. Theriogenology. 2005;63(5):1290-1297.

Osuagwuh UI, Bagla V, Venter EH, Annandale CH, Irons PC. Absence of lumpy skin disease virus in semen of vaccinated bulls following vaccination and subsequent experimental infection. Vaccine. 2007;25(12):2238-2243.

Ahmed WM, Zaher KS. Observations on lumpy skin disease in local Egyptian cows with emphasis on its impact on ovarian function. Afr J Microbiol Res. 2008;2(10):252-257.

Waldock J, Chandra NL, Lelieveld J, Proestos Y, Michael E, Christophides G, et al. The role of environmental variables on Aedes albopictus biology and chikungunya epidemiology. Pathogens and Global Health. 2013;107(5):224-241.

Overgaard H, Stenström TA, Alexander N, Dada N, Lenhart A. Integrated disease management: arboviral infections and waterborne diarrhoea. Bulletin of the World Health Organization. 2021;99(8):583-592.

Balinsky CA, Delhon G, Smoliga G, Prarat M, French RA, Geary SJ, et al. Rapid Preclinical Detection of Sheeppox Virus by a Real-Time PCR Assay. Journal of Clinical Microbiology. 2008;46(2):438-442.

Gupta T, Patial V, Bali D, Angaria S, Sharma M, Chahota R. A review: Lumpy skin disease and its emergence in India. Veterinary research communications. 2020;44:111-118.

Lu G, Xie J, Luo J, Shao R, Jia K, Li S. Lumpy skin disease outbreaks in China, since 3 August 2019. Transboundary and Emerging Diseases. 2021;68(2):216-219.

Badhy SC, Chowdhury MGA, Settypalli TBK, Cattoli G, Lamien CE, Fakir MAU, et al. Molecular characterization of lumpy skin disease virus (LSDV) emerged in Bangladesh reveals unique genetic features compared to contemporary field strains. BMC Veterinary Research. 2021;17(1):61.

Tran HTT, Truong AD, Dang AK, Ly DV, Nguyen CT, Chu NT, et al. Lumpy skin disease outbreaks in vietnam, 2020. Transboundary and Emerging Diseases. 2021;68(3):977-980.

Alemayehu G, Zewde G, Admassu B. Risk assessments of lumpy skin diseases in Borena bull market chain and its implication for livelihoods and international trade. Tropical Animal Health and Production. 2013;45(5):1153-1159.

Soares GMS, Cortelli SC, Duarte PM, Figueiredo LC, Faveri M, Feres M. Mechanisms of action of systemic antibiotics used in periodontal treatment and mechanisms of bacterial resistance to these drugs. Journal of Applied Oral Science. 2012;20(3):295-309.

Abdelbari MA, Elshafeey AH, Abdelbary AA, Mosallam S. Implementing Nanovesicles for Boosting the Skin Permeation of Non-steroidal Anti-inflammatory Drugs. AAPS PharmSciTech. 2023 Sep 28;24(7):195.

Salib FA, Osman AH. Incidence of lumpy skin disease among Egyptian cattle in Giza Governorate, Egypt. Veterinary world. 2011;4(4).

Amin DM, Shehab G, Emran R, Hassanien RT, Alagmy GN, Hagag NM, et al. Diagnosis of naturally occurring lumpy skin disease virus infection in cattle using virological, molecular, and immunohistopathological assays. Veterinary world. 2021;14(8):2230.

Bianchini J, Simons X, Humblet MF, Saegerman C. Lumpy skin disease: a systematic review of mode of transmission, risk of emergence and risk entry pathway. Viruses. 2023 Jul 25;15(8):1622.

Haegeman A, De Clercq K, Venter E, Saegerman C, Tuppurainen E, Mostin L, et al. Comparative Evaluation of Lumpy Skin Disease Virus-Based Live Attenuated Vaccines. Vaccines. 2021;9(5):473.

Zewdie G, Derese G, Getachew B, Belay H, Akalu M. Review of sheep and goat pox disease: current updates on epidemiology, diagnosis, prevention and control measures in Ethiopia. Animal Diseases. 2021;1(1):28.

Tuppurainen ESM, Venter EH, Coetzer JAW, Bell-Sakyi L. Lumpy skin disease: Attempted propagation in tick cell lines and presence of viral DNA in field ticks collected from naturally-infected cattle. Ticks and Tick-borne Diseases. 2015;6(2):134-140.

Katsoulos PD, Chaintoutis SC, Dovas CI, Polizopoulou ZS, Brellou GD, Agianniotaki EI, et al. Investigation on the incidence of adverse reactions, viraemia and haematological changes following field immunization of cattle using a live attenuated vaccine against lumpy skin disease. Transboundary and Emerging Diseases. 2018;65(1):174-185.

European Food Safety A, Calistri P, De Clercq K, Gubbins S, Klement E, Stegeman A, et al. Lumpy skin disease epidemiological report IV: data collection and analysis. EFSA Journal. 2020;18(2):e06010.

Babiuk S. Treatment of Lumpy Skin Disease. In: Tuppurainen ESM, Babiuk S, Klement E, editors. Lumpy Skin Disease. Cham: Springer International Publishing; 2018.81.

Kasem S, Saleh M, Qasim I, Hashim O, Alkarar A, Abu-Obeida A, et al. Outbreak investigation and molecular diagnosis of Lumpy skin disease among livestock in Saudi Arabia 2016. Transboundary and Emerging Diseases. 2018;65(2):e494-e500.

Abutarbush SM, Tuppurainen ESM. Serological and clinical evaluation of the Yugoslavian RM65 sheep pox strain vaccine use in cattle against lumpy skin disease. Transboundary and Emerging Diseases. 2018;65(6):1657-1663.

Boumart Z, Daouam S, Belkourati I, Rafi L, Tuppurainen E, Tadlaoui KO, et al. Comparative innocuity and efficacy of live and inactivated sheeppox vaccines. BMC Veterinary Research. 2016;12(1):133.

World Organisation for Animal H. Terrestrial animal health code: Office international des épizooties; 2005.

Hamdi J, Boumart Z, Daouam S, El Arkam A, Bamouh Z, Jazouli M, et al. Development and Evaluation of an Inactivated Lumpy Skin Disease Vaccine for Cattle. Veterinary Microbiology. 2020;245:108689.

Nash AA, Dalziel RG, Fitzgerald JR. Mims' pathogenesis of infectious disease: Academic Press; 2015.

Kitching RP. Vaccines for lumpy skin disease, sheep pox and goat pox. Developments in biologicals. 2003;114:161-167.

Wolff J, Krstevski K, Beer M, Hoffmann B. Minimum infective dose of a lumpy skin disease virus field strain from North Macedonia. Viruses. 2020 Jul 16;12(7):768.

Haegeman A, De Leeuw I, Mostin L, Campe WV, Aerts L, Venter E, Tuppurainen E, Saegerman C, De Clercq K. Comparative evaluation of lumpy skin disease virus-based live attenuated vaccines. Vaccines. 2021 May 8;9(5):473.

Tuppurainen ESM, Antoniou SE, Tsiamadis E, Topkaridou M, Labus T, Debeljak Z, et al. Field observations and experiences gained from the implementation of control measures against lumpy skin disease in South-East Europe between 2015 and 2017. Preventive Veterinary Medicine. 2020;181:104600.

Lojkić I, Šimić I, Krešić N, Bedeković T. Complete Genome Sequence of a Lumpy Skin Disease Virus Strain Isolated from the Skin of a Vaccinated Animal. Genome Announcements. 2018;6(22):10-128.

Saltykov YV, Kolosova AA, Filonova NN, Chichkin AN, Feodorova VA. Genetic evidence of multiple introductions of lumpy skin disease virus into Saratov Region, Russia. Pathogens. 2021 Jun 7;10(6):716.

Jamil M, Latif N, Bano R, Ali SA, Qaisar MA, Ullah N, et al. Lumpy skin disease: an insights in Pakistan. Pakistan Journal of Medical & Health Sciences. 2022;16(06):824.

Pakistan Economic Survey 2022-2023. Economic Adviser’s Wing, Finance Division, Government of Pakistan, Islamabad; 2023.

Molla W, de Jong MCM, Gari G, Frankena K. Economic impact of lumpy skin disease and cost effectiveness of vaccination for the control of outbreaks in Ethiopia. Preventive Veterinary Medicine. 2017;147:100-107.

Tuppurainen ESM, Oura CAL. Review: Lumpy Skin Disease: An Emerging Threat to Europe, the Middle East and Asia. Transboundary and Emerging Diseases. 2012;59(1):40-48.

Elhaig MM, Selim A, Mahmoud M. Lumpy skin disease in cattle: Frequency of occurrence in a dairy farm and a preliminary assessment of its possible impact on Egyptian buffaloes. Onderstepoort Journal of Veterinary Research. 2017;84(1):1-6.

Abdallah FM, El Damaty HM, Kotb GF. Sporadic cases of lumpy skin disease among cattle in Sharkia province, Egypt: Genetic characterization of lumpy skin disease

virus isolates and pathological findings. Veterinary World. 2018;11(8):1150.

Ochwo S, VanderWaal K, Ndekezi C, Nkamwesiga J, Munsey A, Witto SG, et al. Molecular detection and phylogenetic analysis of lumpy skin disease virus from outbreaks in Uganda 2017–2018. BMC Veterinary Research. 2020;16(1):66.

Datten B, Sharma S, Rudayni HA, Ashraf MS, Kumar S, Alneghery LM, et al. An Extensive Examination of the Warning Signs, Symptoms, Diagnosis, Available Therapies, and Prognosis for Lumpy Skin Disease. Viruses. 2023;15(3):604.

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Published

2025-04-30

How to Cite

Ali Abbas, F., Batool, S., Riaz Malik, I., Abbas, A., Nawaz, Z., Shafique, M., & Muniiru, L. (2025). Lumpy skin disease in Pakistan: unraveling the outbreak and charting future horizons. NUST Journal of Natural Sciences, 10(1). https://doi.org/10.53992/njns.v10i1.248