Synthesis, Structural characterization, and Alkaline phosphatase inhibition studies of transition metal complexes of (e)-4-((3,5-dichlorophenyl) amino)-4-oxobut-2-enoic acid

Authors

  • Khurram Shahzad Munawar Institute of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan
  • Afshan Rizwan Department of Chemistry, University of Mianwali, Mianwali, 42200, Pakistan
  • Syed Mustansar Abbas Department of Chemistry, School of Science, University of Management and Technology, Lahore, Pakistan
  • Shabbir Hussain Institute of Chemistry, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, 64200, Pakistan

DOI:

https://doi.org/10.53992/njns.v9i1.142

Keywords:

Metal carboxylates, FT-IR, UV-visible, ALP inhibition, Molar conductance

Abstract

Ligand, its sodium salt and four new metals (Zn (II), Cu (II), VO(IV) and Cd (II)) carboxylate complexes have been prepared and characterized by FT-IR, conductometry, and UV-visible spectroscopy. The prepared compounds are pure and obtained in the solid state. They have sharp melting points and have good yield. FT-IR spectroscopy proved that carbonyl and amine groups are not involved in metal-ligand coordination. The ligand was coordinated through the carboxylic group upon complex formation. The molar conductance data reveals that the compounds exhibit non-electrolytic properties, primarily attributable to their notably low conductance values. A broad band in the FT-IR spectrum of copper complex represents the presence of water molecules. UV-visible spectral data proved that the synthesized compounds have shown π-π* and n-π* transitions, which indicated that all the compounds are aromatic. Various concentrations of the synthesized compounds were employed to investigate their inhibitory effect on the alkaline phosphatase (ALP) enzyme, conclusively demonstrating their ability to inhibit its activity.

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Published

2024-04-17

How to Cite

Khurram Shahzad Munawar, Afshan Rizwan, Syed Mustansar Abbas, & Shabbir Hussain. (2024). Synthesis, Structural characterization, and Alkaline phosphatase inhibition studies of transition metal complexes of (e)-4-((3,5-dichlorophenyl) amino)-4-oxobut-2-enoic acid. NUST Journal of Natural Sciences, 9(1). https://doi.org/10.53992/njns.v9i1.142