Comparison of the Frequency of Raised Level of Anti-Thyroid Peroxidase Antibody in the Patients of Hypothyroidism and the Euthyroids

Authors

  • Sara Khan
  • Sibgha Bashir
  • Faghia Shahid
  • Ayesha Siddiqa
  • Muhammad Rizwan Hafeez
  • Sarmad Mehmood

DOI:

https://doi.org/10.53992/njns.v5i1.31

Keywords:

Hypothyroidism, euthyroids, anti-thyroid peroxidase antibody

Abstract

The goal of this study was to compare the frequency of raised level of anti-thyroid peroxidase antibody in patients of hypothyroidism and the euthyroids. This case-control study was carried out at the department of Pathology, Quaid e Azam Medical College/Bahawal Victoria Hospital, Bahawalpur, from October 1, 2018 to Setember 30, 2019 and the subjects were selected by the non-probabilty consecutive sampling technique. The frequency of raised level of anti-thyroid peroxidase antibody in patients of hypothyroidism and the euthyroids was compared. In the present study, the mean age of the patients with cases of hypothyroidism was 32 ± 10 years, and the mean age of controls was 32 ± 10 years. Raised anti-thyroid peroxidase antibodies were found in 20 (28.99%) cases and 5 (7.25%) controls. After applying a Chi-squared test, a statistically significant (P = .00) difference in the level of anti-thyroid peroxidase antibodies between the cases and controls was detected. The presence of raised anti-thyroid peroxidase antibodies was also significantly associated with age and female gender. In conclusion the early screening of the anti-thyroid peroxidase antibodies specially in women above 30-years would notably affect the outcome of the disease with congruent disease management.he euthyroids was compared. In the present study, the mean age of the patients with cases of hypothyroidism was 32 ± 10 years, and the mean age of controls was 32 ± 10 years. Raised anti-thyroid peroxidase antibodies were found in 20 (28.99%) cases and 5 (7.25%) controls. After applying a Chi-squared test, a statistically significant (P = .00) difference in the level of anti-thyroid peroxidase antibodies between the cases and controls was detected. The presence of raised anti-thyroid peroxidase antibodies was also significantly associated with age and female gender. In conclusion the early screening of the anti-thyroid peroxidase antibodies specially in women above 30-years would notably affect the outcome of the disease with congruent disease management.

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Published

2021-01-18 — Updated on 2021-05-29

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